Sex- and BMI-related differences in risk factors for coronary artery disease in patients with type 2 diabetes mellitus |
| |
Authors: | S Bo L Gentile P Cavallo-Perin P Vineis V Ghia |
| |
Institution: | (1) Department of Internal Medicine, University of Turin, C.so A.M. Dogliotti 14, I-10126 Turin, Italy, IT;(2) Diabetic Clinic, Department of Medicine, Hospital of Asti, Asti, Italy, IT;(3) Department of Biomedicine and Human Oncology, University of Turin, Turin, Italy, IT |
| |
Abstract: | There are contrasting data about the relationship between obesity and macrovascular complications in type 2 diabetes mellitus,
and it is not known if risk factors for coronary artery disease are different in normal weight and overweight or obese patients.
All 2113 patients with type 2 diabetes mellitus referring to the Diabetic Clinic of Asti were studied. Patients were divided
into tertiles of body mass index, according to their sex (BMI < 26.9; ≥ 26.9 and < 31.4; ≥ 31.4 kg/m2 for females and BMI < 25.7; ≥ 25.7 and < 28.8; ≥ 28.8 kg/m2 for males). Age, BMI, duration of diabetes, blood pressure, HbA1c total cholesterol, HDL-cholesterol, LDL-cholesterol, and prevalence of insulin treatment and hypertension were higher in
females, whereas exercise, alcohol intake, smoking habits and prevalence of dyslipidemia were higher in males. An increase
in BMI was associated with an increase in HbA1c, number of cigarettes/day, blood pressure, triglycerides, C-peptide, prevalence of hypertension and dyslipidemia, and with
a decrease in age, duration of diabetes and HDL-cholesterol values. In spite of an apparently worse cardiovascular risk profile,
females showed a 50% lower prevalence of CAD than males and the prevalence of CAD was not significantly different in obese
compared to other BMI categories. Multiple logistic regression showed that risk factors for CAD were different in males and
females and similar in the lower tertiles of BMI, while different in the highest. In obese females, risk factors for CAD were
age, reduced HDL-cholesterol and increased HbA1c levels; in males they were years of smoking and duration of diabetes. These data suggest that in type 2 diabetes, risk factors
for CAD are different in the two sexes and in patients with the highest BMI compared to the normal and overweight subjects;
blood glucose control and duration of diabetes seem more important than conventional cardiovascular risk factors in obese
patients.
Received: 11 May 1998 / Accepted in revised form: 30 July 1999 |
| |
Keywords: | Type 2 diabetes mellitus Cardiovascular risk factors BMI |
本文献已被 PubMed SpringerLink 等数据库收录! |
|