| 淫羊藿苷对急性早幼粒白血病细胞体内外效应的研究 |
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| 引用本文： | 葛林阜,董政军,姜国胜,黄宁,唐天华,王鲁群,马焕文,孔凡盛,周芳,郭鹏. 淫羊藿苷对急性早幼粒白血病细胞体内外效应的研究[J]. 中华肿瘤防治杂志, 2001, 8(6): 622-624 |
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| 作者姓名： | 葛林阜 董政军 姜国胜 黄宁 唐天华 王鲁群 马焕文 孔凡盛 周芳 郭鹏 |
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| 作者单位： | 1. 济南军区总医院血液科、动物实验中心,
2. 山东省医学科学院血液肿瘤研究室, |
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| 摘 要： | 目的 :探讨淫羊藿苷 (ICA)对急性早幼粒白血病细胞的诱导分化作用。方法 :采用ICA与全反式维甲酸 (ATRA)对比试验 ,观察ICA在体外及小鼠体内对白血病细胞增殖分化的影响。结果 :ICA在体内外对白血病细胞均有较明显的诱导分化和抑制增殖作用 ,且与ATRA合用可产生明显的协同效应。结论 :ICA具有明显的抗白血病细胞作用
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| 关 键 词： | 淫羊藿苷 急性早幼粒白血病细胞 全反式维甲酸 诱导 分化 |
| 文章编号： | 1009-4571(2001)06-0622-03 |
| 修稿时间： | 2001-09-03 |
Experiment Study on the Effect of ICA on HL-60 Cells in Vivo and in Vitro |
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| Ge Lin fu,DONG Zheng jun,JIANG Guo sheng,et al.. Experiment Study on the Effect of ICA on HL-60 Cells in Vivo and in Vitro[J]. Chinese Journal of Cancer Prevention and Treatment, 2001, 8(6): 622-624 |
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| Authors: | Ge Lin fu DONG Zheng jun JIANG Guo sheng et al. |
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| Affiliation: | Ge Lin fu,DONG Zheng jun,JIANG Guo sheng,et al.General Hospital of Jinan Command PLA,Jinan 250031,China |
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| Abstract: | Objective To study the effect of ICA on the proliferation and differentiation of HL 60 cells.Methods The effect of ICA on the proliferation and differentiation of HL 60 cells were compared with ATRA and evaluated in vivo and in vitro.Results ICA can induce the differentiation of HL 60 cells in vivo and in vitro,which effect was promoted by ATRA.Conclusion The results suggested that the proliferation of HL 60 can been distinctly inhibited by ICA. |
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| Keywords: | ICA(icarlin) HL 60 cells ATRA proliferation differentiation |
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