冠心病患者合并糖代谢异常血浆脑钠肽、超敏C反应蛋白水平的变化的研究

目的比较单纯冠心病（CHD）和冠心病合并三种不同类型糖代谢异常（空腹血糖调节受损IFG、糖耐量减低IGT、糖尿病DM）患者血浆B型钠尿肽（BNP）和血清超敏c反应蛋白（hs-CRP）水平的相关性。方法按冠心病及糖代谢异常诊断标准，将180例患者分为单纯冠心病组（CHD）、单纯糖代谢异常组、冠心病（CHD）合并空腹血糖调节受损（IFG）组、冠心病（CHD）合并糖耐量减低（IGT）组、冠心病（CHD）合并糖尿病（DM）组和正常对照组（无冠心病和糖代谢异常、6组，各组均30倒。采用免疫透射比浊法检测血清hs—CRY，免疫荧光快速测定法测定BNP值。结果单纯冠心病组（CHD）、单纯糖代谢异常组、CHD舍并IFG组、CHD合并IGT组、CHD合并DM组患者的hs—CRP和BNP浓度水平均高于正常对照组（P〈0．05），CHD合并IFG组、CHD合并IGT组、CHD合并DM组均高于单纯糖代谢异常组和单纯冠心病组（P〈0．05），CHD合并DM组高于CHD合并IFG组、CHD合并IGT组、单纯冠心病组、单纯糖代谢异常组（P〈0．05），CHD合并IFG和CHD合并IGT组，差异无统计学意义（P〉0．05）。结论冠心病合并各种糖代谢异常（IFG、IGT、DM）患者hs—CRP和BNP浓度水平均显著升高，其中，冠心病合并DM患者的hs—CRP和BNP浓度水平升高最显著。

The study on plasma brain natriuretic peptide and high sensitivity C - reactive protein level in coronary heart disease in patients with glucose metabolic abnormality

Objective To study the correlation of plasma level of B- type Natriurotie Pepfide（BNP） and serum level of high sensitivity C - reactive protein（hs - CRP） in the patients with coronary, heart disease（CHD） only and coronary heart disease with three different types of glucometabolle abnormality as follows ： Impaired Fasting Glucose （IFG） ,Impaired Glucose Tolerance（ IGT）, Diabetes Mellitus（ DM）. Methods According to the diagnostic criteria of coronary, heart disease and glueometabolic abnormality, 180 patients were divided into six groups： simple CHD, simple glucometabolie abnormalit）, CHD with IFG、 CHD with IGT,CHD with DM,and normal controlled group（ no coronary heart disease and no glucometabolic abnormality）. Each group consists of 30 cases. Serum level of hs - CRP was detected with immune transmission than turbidity method and plasma level of BNP was detected with fast determination method. Results The serum level of hs - CRP and plasma level of BNP in simple CHD,simple glacometabohc abnormality group,CHD with IFG group,CHD with IGT group,CHD with DM group were higher than those in normal controlled group（P 〈 0.05） .The serum level of hs- CRP and plasma level of BNP in CHD with IFG group,CHD with IGT group,CHD with DM group were higher than those in simple coronary heart disease group and simple glucometabolic abnormality group（P 〈 0.05） ,The serum level of hs - CRP and plasma level of BNP in CHD with DM group were higher than those in CHD With IFG group,CHD with IGT group,slmple coronary heart disease group、simple glueometabolic abnormality group（P 〈 0.05） .The serum level of hs - CRP and plasma level of BNP in CHD with IFG group and CHD with IGT group had not statistically difference. Conclusions The serum level of hs - CRP and plasma level of BNP significantly increased in CHD with three different types of glacometabolic abnormality（ IFG, IGT, DM） patients. Especially, hs - CRP and BNP increased in CHD with DM most significantly.