吡喹酮对大鼠单胺介质的影响

吡喹酮是一种新型广谱抗寄生虫药。本文报道用高效液相色谱-电化学检测器联用的方法,测定单胺类神经介质及其代谢物的含量,研究吡喹酮对大鼠单胺类介质的影响。结果表明:吡喹酮(250 mg/kg使脑DA的酸性代谢产物DOPAC,HVA和5-HT的代谢物5-HIAA的含量明显升高,而对DA和NA含量无明显影响。DA酸性代谢物和5-HIAA升高表明吡喹酮能增加DA和5-HT的转换率。

INFLUENCE OF PRAZIQUANTEL ON MONOAMINE TRANSMITTERS IN RAT BRAIN

Effects of praziquantel on monoamines and their metabolite contents were studied using HPLC-electrochemical detector. Praziquantel was found to increase the acidic metabolites of dopamine, DOPAC and HVA, and of 5-HT and 5-HIAA levels in the striatum and limbic areas. The increase in DOPAC and HVA reached their peaks 0.5～1 h after a dose of 500 mg/kg in the two regions, while the dopamine and noradrenaline levels were unchanged. The elevation of DOPAC, HVA and 5-HIAA was in dose-dependent manner. When higher dose of praziquantel (1000 mg/kg) was given, the values of dopamine in the striatum and of noradrenaline in the limbic area were lowered. The results show that the turnover rates of dopamine and 5-HT were increased.