柴胡滴丸联合藿香正气滴丸治疗SARS的临床观察

目的 早期应用柴胡滴丸联合藿香正气滴丸治疗SARS的临床疗效观察。方法随机选取22例SARS确诊病例，依照年龄、性别、职业为控制因素配成11对，每对中有1例在应用对症治疗的同时，给予柴胡滴丸联合藿香正气滴丸治疗，持续观察13天，检测患者肌酸激酶、乳酸脱氢酶、血清钠水平等临床指标，并比较中性白细胞绝对数，氧合指数及甲基泼尼松日最大用量和总用量。结果早期应用柴胡滴丸联合藿香正气滴丸治疗SARS的患者的肌酸激酶、乳酸脱氢酶、中性白细胞绝对数及氧合指数均有良好影响，并能减少患者应用糖皮质激素的日最大用量。结论早期应用柴胡滴丸联合藿香正气滴丸治疗SARS可以减轻患者肺脏损伤，减轻白细胞依赖性炎症反应及激素用量。

Clinical Observation on Treatment of SARS with Combination of Chaihu Droplet Pill and Huoxiang Zhengqi Droplet Pill

ObjectiveTo observe the effect of combination treatment with Chaihu Droplet pill (CHDP) and Huoxiang Zhengqi Droplet pill (HZDP) in treating severe acute respiratory syndrome (SARS) in early stage. MethodsTwenty-two patients of SARS were randomly selected and paired according to such controlling factors as age,sex and profession into 11 couples. To them all symptomatic treatment was applied,combined CHDP and HZDP (CH-HZ) was given additionally to one of each couple randomly. The treatment was lasted for 13 days to investigate the changes of the clinical indexes such as creatine kinase (CK),lactate dehydogenase (LDH) and serum sodium levels. ResultsEarly applying of CH-HZ treatment showed good effects in improving CK,LDH,oxygenation index and absolute value of neutrophils,and could reduce the daily maximal dosage of glucocorticoid needed for SARS patients. ConclusionEarly application of CH-HZ treatment in treating SARS could alleviate the injury in lung of SARS patients and the neutrophil dependent inflammatory reaction,and reduce the dosage of glucocorticoid used.