云南省HIV-1感染儿童一线抗病毒治疗病毒学反弹影响因素研究

目的 观察云南省艾滋病病毒(HIV-1)感染儿童抗病毒治疗(ART)的疗效,探讨ART过程中出现病毒学反弹的影响因素.方法 通过"国家艾滋病抗病毒治疗信息系统"收集资料,并进行描述性分析,采用COX比例风险回归模型分析发生病毒学反弹的影响因素.结果 2005年1月1日至2015年12月31日,云南省随访治疗1年以上且在...

Risk factors of viral load rebound on first-line antiretroviral therapy in HIV-infected children in Yunnan

Objective To understand the situation of anti-retroviral therapy(ART)and evaluate the therapeutic effect and the factors influencing viral load rebound among children in Yunnan province Methods Data were collected from the National ART information system,and analyzed with Cox proportional hazard regression model for the risk factors.Results The incidence rate of viral load rebound within 13-24 months(40.71%)were higher than 25-36 months(11.76%)and 37 months(4.84%).Hazard ratio of children who had doses missed and had toxic side-effect events were 4.111 times(HR=4.111,95%CL=2.679-6.310)and 1.767 times(HR=1.767,95%CL=0.994-3.141)of children who did not have those events.Conclusion The incidence rate of viral load rebound in children occurs mainly in the period of 13-24 months after treatment.Drug adherence and toxic side-effect events are the main factors causing viral load rebound.The occurrence of viral load rebound in ART can be reduced by improving children’s adherence.