| 新型降糖药物在三种常见青少年的成年起病型糖尿病亚型上的应用 |
| |
| 引用本文： | 段倩雯,彭慧芳,马瑜瑾,姜宏卫. 新型降糖药物在三种常见青少年的成年起病型糖尿病亚型上的应用[J]. 中华内分泌代谢杂志, 2021, 0(3): 262-266 |
| |
| 作者姓名： | 段倩雯 彭慧芳 马瑜瑾 姜宏卫 |
| |
| 作者单位： | 河南科技大学临床医学院 |
| |
| 基金项目： | 河南省省直医疗机构服务能力提升工程建设项目(2017);河南省中国科学院科技成果转移转化项目(2018105)。 |
| |
| 摘 要： | 青少年的成年起病型糖尿病(maturity-onset diabetes of the young, MODY)是一种异质性的单基因糖尿病，其中MODY1、MODY2和MODY3是常见的MODY亚型。近年来胰升糖素样肽1受体激动剂(GLP-1RA)、二肽基肽酶4抑制剂(DPP-4i)、钠-葡萄糖共转运蛋白2抑制剂(SG...
|
| 关 键 词： | 青少年的成年起病型糖尿病 肝细胞核因子1α 葡萄糖激酶 肝细胞核因子4α 新型降糖药物 |
Application of new hypoglycemic drugs of the three most common types of maturity-onset diabetes of the young |
| |
| Duan Qianwen,Peng Huifang,Ma Yujin,Jiang Hongwei. Application of new hypoglycemic drugs of the three most common types of maturity-onset diabetes of the young[J]. Chinese Journal of Endocrinology and Metabolism, 2021, 0(3): 262-266 |
| |
| Authors: | Duan Qianwen Peng Huifang Ma Yujin Jiang Hongwei |
| |
| Affiliation: | (Medical Key Laboratory of Hereditary Rare Diseases of Henan,Luoyang City Clinical Research for Endocrinology and Metabolism,Department of Endocrinology and Metabolism,the First Affiliated Hospital,and College of Clinical Medicine of Henan University of Science and Technology,Luoyang 471003,China) |
| |
| Abstract: | Maturity-onset diabetes of the young(MODY)is a heterogeneous monogenic diabetes,in which MODY1,MODY2,and MODY3 are the most common subtypes.In recent years,new hypoglycemic drugs such as glucagon-like peptide-1 receptor agonists(GLP-1RA),dipeptidyl peptidase-4 inhibitors(DPP-4i),sodium-glucose co-transporter 2 inhibitors(SGLT2i),and glucokinase activators(GKA)have made good progress in the treatment of diabetes.Based on the latest basic and clinical evidence,the article reviews the pathogenesis,clinical features,diagnosis and treatment progress of new hypoglycemic drugs of the above three types of MODY,aiming to develop safer and more effective new ways for the diagnosis and treatment of MODY. |
| |
| Keywords: | Maturity-onset diabetes of the young Hepatocyte nuclear factor 1α Glucokinase Hepatocyte nuclear factor 4α New hypoglycemic drugs |
| 本文献已被 维普 等数据库收录！ |
|
