海南地区百岁老年人免疫球蛋白及补体表达特征研究

目的:调查研究海南地区百岁老年人血清免疫球蛋白及补体含量特征。方法:收集海南省969例百岁老年人空腹静脉血标本为百岁老年人组，364例高龄老年人为对照组。检测血清免疫球蛋白A、血清免疫球蛋白G、血清免疫球蛋白M、血清免疫球蛋白E、血清免疫球蛋白轻链κ、血清免疫球蛋白轻链λ、补体C3、补体C4含量。分析不同年龄、性别、民...

Study on the characteristics of immunoglobulin and complement expression in centenarians in Hainan

Objective To investigate the characteristics of serum immunoglobulin and complement levels in centenarians in Hainan.Methods Fasting venous blood samples from 969 centenarians in Hainan province were collected and from 364 seniors serving as the control group.Levels of serum immunoglobulin A,G,M and E,immunoglobulin light chainκandλ,and complement C3 and C4 were measured.Serum immunoglobulin and complement levels were analyzed in subjects based on age,sex,ethnicity,diet and smoking.Results Serum levels of immunoglobulin G and E,and immunoglobulin light chainκwere higher in the centenarian group than in the control group[15.9(13.8,18.3)g/L vs.14.9(13.1,16.9)g/L;270.0(85.5,851.0)vs.180.5 kU/L(58.0,556.2)kU/L,4.1(3.5,4.9)g/L vs.4.0(3.1,4.6)g/L,P<0.05].Serum levels of immunoglobulin M,and complement C3 and C4 were lower in the centenarian group than in the control group[1.0(0.7,1.4)g/L vs.1.1(0.8,1.5)g/L,1.0(0.9,1.2)vs.1.1(1.0,1.3),0.2(0.2,0.3)vs.0.3(0.2,0.3),P<0.05].Serum levels of immunoglobulin M and complement C3 were higher in female centenarians than in male centenarians[1.1(0.7,1.4)vs.1.0(0.7,1.3),1.0(0.9,1.1)vs.1.0(0.8,1.1),P<0.05].There were significant differences in immunoglobulin A,G and E,and immunoglobulin light chainκandλbetween centenarians of different ethnicities(P<0.01).Serum immunoglobulin M levels were higher in centenarians with a long history of milk-drinking than in those without the history[1.2(0.8,1.5)vs.1.0(0.7,1.4),P<0.01].Conclusions Serum levels of immunoglobulins and complements are different among centenarians of different ages,genders,ethnicities and diet habits.Factors such as advanced age,female gender,ethnic minority and milk drinking tend to promote the expression of immunoglobulins and complements.