吗啉硝唑与奥硝唑治疗厌氧菌感染的疗效、安全性及药物经济学比较

目的比较吗啉硝唑氯化钠注射液、奥硝唑注射液和注射用奥硝唑治疗厌氧菌感染的有效性、安全性和经济性。方法回顾性分析本院2017年1月至2019年12月252例使用硝基咪唑类抗菌药物治疗厌氧菌感染患者的病例资料。其中,吗啉硝唑组(吗啉硝唑氯化钠注射液100 mL,q12h,静脉滴注)93例,奥硝唑注射液组(奥硝唑注射液3 mL,q12h,静脉滴注)82例,注射用奥硝唑组(注射用奥硝唑0.5 g,q12h,静脉滴注)77例,疗程均为5 d。收集患者治疗期间的成本、效果和不良反应数据,进行分析评价。结果吗啉硝唑组、奥硝唑注射液组和注射用奥硝唑组的治疗总有效率分别为96%、90%和84%,不良反应发生率分别为9%、10%和22%,3组间均有显著差异(P<0.05)。成本-效果分析显示,与奥硝唑注射液组比较,注射用奥硝唑组的增量成本效果比为-279元,吗啉硝唑组为9051元。结论三种治疗方案中吗啉硝唑氯化钠注射液治疗厌氧菌疗效高、不良反应发生率低,而奥硝唑注射液更具有经济性。

Comparison of efficacy,safety and pharmacoeconomics of morinidazole and ornidazole in treatment of anaerobic bacteria infection

AIM To compare the efficacy,safety and drug economics of morinidazole and sodium chloride injection,ornidazole injection,and ornidazole for injection in treatment of anaerobic bacteria infection.METHODS The clinical data of 252 cases of patients with anaerobe infection treated with nitroimidazole antibiotics in our hospital from January 2017 to December 2019 were retrospectively analyzed.Among them,93 cases were treated with morinidazole and sodium chloride injection(100 mL,q12h,ivgtt),82 cases were treated with ornidazole injection(3 mL,q12h,ivgtt),and 77 cases were treated with injection for ornidazole(0.5 g,q12h,ivgtt).The treatment courses were all 5 days.The data of cost,effect and adverse reactions during the treatment were collected for analysis and evaluation.RESULTS The effective rates of the morinidazole group,ornidazole injection group and ornidazole for injection group were 96%,90%and 84%,respectively;the incidence of adverse reactions were 9%,10%and 22%,respectively.There were significant differences in the effective rates and the incidence of adverse reactions among the three groups(P<0.05).Compared with the ornidazole injection group,the cost-effectiveness analysis showed that the incremental cost-effectiveness ratio(ICER)of the ornidazole for injection group was-279 yuan,and the ICER of the mornidazole group was 9051 yuan.CONCLUSION Among the three treatment schemes,morpholinidazole and sodium chloride injection has high efficacy and low incidence of adverse reactions in the treatment of anaerobic bacteria,while ornidazole injection is more economical.