| 干细胞与结核分枝杆菌交互作用的研究进展 |
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| 引用本文： | 郭倩,申晨,申阿东. 干细胞与结核分枝杆菌交互作用的研究进展[J]. 中国防痨杂志, 2021, 43(2): 186-189. DOI: 10.3969/j.issn.1000-6621.2021.02.015 |
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| 作者姓名： | 郭倩 申晨 申阿东 |
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| 作者单位： | 100045.国家儿童医学中心 首都医科大学附属北京儿童医院 北京市儿科研究所呼吸疾病研究室 儿童呼吸道感染性疾病研究北京市重点实验室 |
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| 基金项目： | 北京市自然科学基金(7202043)。 |
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| 摘 要： | 结核分枝杆菌是引起人类结核病的主要病原菌。作为胞内致病菌,结核分枝杆菌在宿主细胞内潜伏或增殖,其不仅能被宿主吞噬细胞所吞入,还可入侵以造血干细胞和间充质干细胞为代表的干细胞。由于干细胞具有自我复制、多能分化、高度迁移和免疫调节等特性,其在结核病发生和发展中的作用不可忽视。作者主要从结核分枝杆菌与干细胞之间的交互作用这一角度对结核病的发病机制和防治策略进行综述和展望。
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| 关 键 词： | 干细胞 分枝杆菌 结核 交互分析 结核 免疫调节 |
| 收稿时间： | 2020-10-21 |
Research progress of stem cells in Mycobacterium tuberculosis infection |
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| GUO Qian,SHEN Chen,SHEN A-dong. Research progress of stem cells in Mycobacterium tuberculosis infection[J]. The Journal of The Chinese Antituberculosis Association, 2021, 43(2): 186-189. DOI: 10.3969/j.issn.1000-6621.2021.02.015 |
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| Authors: | GUO Qian SHEN Chen SHEN A-dong |
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| Affiliation: | Beijing Key Laboratory of Pediatric Respiratory Infection Diseases, Beijing Pediatric Research Institute, Respiratory Disease Laboratory of Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing 100045, China |
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| Abstract: | Tuberculosis is mainly caused by an intracellular pathogen—Mycobacterium tuberculosis,which can lurk or proliferate in host cells.It can also invade stem cells such as hematopoietic stem cells and mesenchymal stem cells.Stem cells are capable of self-replication,pluripotent differentiation,high migration and immune regulation,thus the role of them in the occurrence and development of tuberculosis can not be ignored.We mainly reviewed the pathogenesis and prevention and treatment strategies of tuberculosis through the interaction between Mycobacterium tuberculosis and stem cells. |
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| Keywords: | Stem cells Mycobacterium tuberculosis Transactional analysis Tuberculosis Immuno-modulation |
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