老年男性慢性心力衰竭患者血清睾酮和雌二醇水平测定及临床意义

目的探讨老年男性慢性心力衰竭(CHF)患者血清睾酮(T)和雌二醇(E2)水平改变的临床意义。方法采用化学发光法(CLIA)测定63例老年男性CHF患者血清T、E2水平,同时设23例同龄健康人为对照组。结果①CHF组血清T水平均显著低于对照组(P<0.05);心功能Ⅱ、Ⅲ、Ⅳ级组间比较T水平依次递减(P<0.05);②血清T水平与心功能分级呈负相关(r=-0.543,P<0.05),与左心室射血分数(LVEF)呈显著正相关(r=0.399,P<0.05),但与血清E2水平无显著相关性(P>0.05)。结论老年男性CHF患者血清T水平测定对其CHF严重程度和预后判断具有重要的临床意义,而血清E2与男性CHF心功能无相关性。

A study on the serum testosterone and estradiol levels in the aged males with chronic heart failure

Objective To explore the changes of the serum testosterone （T）and estradio （E2）levels in aged males with chronic heart failure （CHF）. Methods The serum T and E2 levels were determined by CLIA in 63 aged males with CHF and 23 age-matched healthy individuals. Results （1）Mean serum T （310.56±124.12） levels in patients with CHF were significantly lower than that in control group （423.00± 106.59） （t=3.853,P〈0.05）, but the E2 value was no difference. The difference in the mean serum T was significant in different stage（stage Ⅱ, Ⅲ, Ⅳ） CHF patients （P〈0.05）; （2）The levels of serum T levels were negatively correlated with the classification of NYHA（r=-0.468,P〈0.05）,the levels of serum T levels were positively correlated with LVEF （r=0.399, P〈0.05）. Conclusion h may be aided to estimated the prognosis and to study the pathological mechanism by determinetion of the levels of the serumT in CHF patients;the levels of the serumT in CHF patients can be used as an index to judge the degree of CHF.