nm23-H1和P53表达与乳腺肿瘤浸润转移的关系

目的：研究ｎｍ２３－Ｈ１、Ｐ＾５３蛋白在乳腺肿瘤中表达与浸关系。方法：应用免疫组织化学Ｓ－Ｐ法对８１例乳腺肿瘤组织进行检测。结果：良性肿瘤两各基因产物ｎｍ２３－Ｈ１、Ｐ＾５３的阳性率分别为１００％和９．１％，乳腺癌则分别为５２．９％和５５．７％。在７０例乳腺癌中，ｎｍ２３－Ｈ１低表达、Ｐ＾５３过表达与浸润程度和淋巴结转移有关，Ｐ＾５３过表达与ｎｍ２３－Ｈ１低表达呈负相关。结论：ｎｍ２３－Ｈ１与Ｐ＾

THE RELATION BETWEEN THE EXPRESSION OF nm23,P53 AND INVASION AND METASTASIS OF HUMAN BREAST NEOPLASM

Objective:To study the relation between invasion,metastasis and the expression of nm23 H 1,P 53 in human breast neoplasms Methods:81 cases of human breast neoplasms were detected with S P immunohistochemocal technique Results:The positive rates of nm23 H 1 and P 53 protein products in benign group were 100% and 9 1% respectively,while they were 52 9% and 55 7% respectively in malignant group In the 70 cases of breast carcinoma,a significant correlation was found that both nm23 H 1 low expression and P 53 overexpression were related to tissues invasion and lymph node metastasis ( P <0 01, P <0 05) There was negative correlation between nm23 H 1 and P 53 expression ( P =0 000 6) Conclusions:The correlation of nm23 H 1 and P 53 expression indicates that they play an important role in breast carcinoma invasion and metastasis,and predict the grade of malignancy and prognosis