TMC-66, a new endothelin converting enzyme inhibitor produced by Streptomyces sp. A5008. |
| |
| Authors: | Y Asai N Nonaka S Suzuki M Nishio K Takahashi H Shima K Ohmori T Ohnuki S Komatsubara |
| |
| Institution: | Discovery Research Laboratory, Tanabe Seiyaku Co., Ltd, Saitama, Japan. |
| |
| Abstract: | A new endothelin converting enzyme (ECE) inhibitor, TMC-66 was isolated from the fermentation broth of Streptomyces sp. A5008. The structure of TMC-66 was elucidated by spectroscopic analyses to be a new member of benzoa]naphthacenequinone class of antibiotics. TMC-66 had a highly selective inhibitory activity for ECE with an IC50 value of 2.9 microM. Taxonomy of the producing strain is also described. |
| |
| Keywords: | |
|
|
