急性冠脉综合征患者血巨噬细胞移动抑制因子和肿瘤坏死因子-α水平改变的探讨

研究表明急性冠脉综合征（ACS）斑块的不稳定性与炎症反应密切相关。巨噬细胞移动抑制因子（MW）和肿瘤坏死因子-α水平（TNF-α）是具有多种生物活性的重要细胞因子，参与一系列炎症和免疫过程，在动脉粥样硬化的形成和发展过程中起到重要作用。本文通过对ACS患者MIF和TNF-α含量的测定，探讨其在ACS浓度的变化及临床意义。

Study on Plasma Level of Macrophage Migration Inhibitory Factor(MIF) and Tumor Necrosis Factor-α (TNF-α) in Patients with Acute Coronary Syndrome(ACS)

Objective To observe plasma MIF and TNF-α levels in patients with ACS and explore their clinical significance in ACS.Methods 58 patients with ACS were recruited,including 30 patients with acute myocardial infarction（AMI）and 28 patients with unstable angina（UA）,24 cases who had normal coronary angiography also were recruited as control group.The degree of coronary artery stenosis was determined by Gensini＇s scores system.Plasma MIF level was measured by ELISA and TNF-α was measured by radioimmunoassay（RIA） method.Results The levels of MIF and TNF-α in ACS group were significantly higher than those in control group（P〈0.01）,and they were higher in AMI subgroup than in UA subgroup（P〈0.01）.The levels of MIF、TNF-α in ACS group were correlated with the degree of coronary artery stenosis（P〈0.05）.Conclusions Increased MIF and TNF-α could not only reflect the severity of ACS,but also predict the potential risk and the degree of coronary artery stenosis in the initial stage of ACS.