| 烟酸缓释片的制备及释放度研究 |
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| 引用本文： | 付桂英,温明铃,潘强,王世岭.烟酸缓释片的制备及释放度研究[J].解放军药学学报,2004,20(6):466-468. |
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| 作者姓名： | 付桂英 温明铃 潘强 王世岭 |
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| 作者单位： | 中国人民解放军第307医院,药剂科,北京,100039;中国人民解放军第307医院,药剂科,北京,100039;中国人民解放军第307医院,药剂科,北京,100039;中国人民解放军第307医院,药剂科,北京,100039 |
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| 摘 要： | 目的 制备烟酸缓释片，进行体外释放度研究。方法 以羟丙甲基纤维素为骨架材料，70％乙醇为粘合剂，采用湿法制粒压片，以紫外分光光度法测定其在不同释放介质中的释放度。结果 所研制的缓释片缓释效果良好，符合零级动力学规律。结论 用羟丙甲基纤维素作为骨架材料能达到较好的缓释作用。
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| 关 键 词： | 烟酸 缓释片 羟丙甲基纤维素 |
| 文章编号： | 1008-9926(2004)06-0466-03 |
| 修稿时间： | 2004年2月19日 |
Preparation of Nicotinic Acid Sustained Release Tablet and Determination of its Dissolution rate |
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| FU Gui-Ying,WEN Ming-Ling,PAN Qiang,WANG Shi-Ling.Preparation of Nicotinic Acid Sustained Release Tablet and Determination of its Dissolution rate[J].Pharmaceutical Journal of Chinese People's Liberation Army,2004,20(6):466-468. |
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| Authors: | FU Gui-Ying WEN Ming-Ling PAN Qiang WANG Shi-Ling |
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| Abstract: | Aim To prepare nicotinic acid sustained released tablets using HPMCK 4M and evaluate its releasing features in vitro.Methods HPMCK 4M was utilized as matrix,70% ethanol was employed as a binding agent to obtain wet granules.The dissolution in different mediums were determined by UV specophotography.Results The drug release behavior could be best described by first-order kinetic equation.Conclusion HPMCK 4M could be used as a matrix to prepare sustained-release tablet of nicotinic acid. |
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| Keywords: | Nicotinic acid Sustained-release tablet HPMC |
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