| 1,6二磷酸果糖对大鼠阿霉素心肌病的防治作用及机理的探讨 |
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| 引用本文： | 赖平,马郁文.1,6二磷酸果糖对大鼠阿霉素心肌病的防治作用及机理的探讨[J].中华儿科杂志,1997,35(7):368-370. |
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| 作者姓名： | 赖平 马郁文 |
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| 作者单位： | 北京医科大学第一医院儿科 |
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| 摘 要： | 为探讨１，６二磷酸果糖（ＦＤＰ）对大鼠阿霉素心肌病的防治作用及其机理，采用Ｗｉｓｔａｒ大鼠３０只，随机分为阿霉素（ＡＤＲ）组、ＡＤＲ＋ＦＤＰ组及对照组。实验６周后进行心肌的光、电镜病理形态学观察。结果：光、电镜下心肌病理损害程度，ＡＤＲ＋ＦＤＰ组较ＡＤＲ组轻；心肌组织的病理等级，ＡＤＲ＋ＦＤＰ组明显低于ＡＤＲ组；心肌细胞线粒体形态计量分析，ＡＤＲ＋ＦＤＰ组线粒体嵴膜的比膜面较ＡＤＲ组有明显增高趋势。提示，ＦＤＰ对大鼠阿霉素心肌病具有防治作用，且ＦＤＰ可能通过改善心肌细胞线粒体的能量代谢机制而发挥作用
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| 关 键 词： | 阿霉素 心肌疾病 果糖二磷酸盐类 |
Protective effects of fructose 1,6 diphosphate on cardiomyopathy in duced by adriamycin in rats and its mechanisms |
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| Lai Ping,Ma Yuwen,Du Junbao,et al..Protective effects of fructose 1,6 diphosphate on cardiomyopathy in duced by adriamycin in rats and its mechanisms[J].Chinese Journal of Pediatrics,1997,35(7):368-370. |
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| Authors: | Lai Ping Ma Yuwen Du Junbao |
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| Institution: | Lai Ping,Ma Yuwen,Du Junbao,et al. Department of Pediatrics,First Hospital of Beijing Medical University,Beijing 100034 |
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| Abstract: | The present study was undertaken to examine the protective effects of fructose 1,6 diphosphate (FDP) on cardiomyopathy induced by adriamycin (ADR) in rats and its mechanisms. Wistar rats ( n =30) were randomly divided into ADR, ADR FDP and control groups. Myocardial histopathological observation was performed after 6 week experiment. The results showed that the myo cardial lesions of rats were less pronounced in ADR FDP group than in ADR group. And the grade of histological changes of rats was much lower in former than in latter. Furthermore, we found that the specific membrane area of mitochondria cristae of rats had a trend of enlargement in ADR FDP group as compared with ADR group. The results of this study suggest that FDP has a preventive effect on cardiomyopathy induced by ADR, which is probably associated with improving energy metabolism of myo cardial mitochondria. |
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| Keywords: | Doxorubicin Myocardial diseases Fructosediphosphates |
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