缺氧对不同组织线粒体功能影响的研究进展

线粒体是有氧呼吸的主要场所,在缺氧条件下,线粒体的形态及能量代谢会发生一系列的变化去适应有限的氧环境。该研究从目前国内外的研究现状出发,分析了缺氧环境下,心肌细胞、脑细胞、肺动脉平滑肌细胞及骨骼肌细胞的线粒体能量产生异常、线粒体膜电位及膜通透性改变、钙离子超载、活性氧产生过多,引起氧化应激、自噬及凋亡等反应,造成线粒体功能障碍,从而引起机体组织损伤;指出了线粒体在适应缺氧过程中的重要性;最后总结了目前关于缺氧对线粒体影响的研究局限性及未来研究方向。

Research progress on the effects of hypoxia on mitochondrial function in different tissues

Mitochondria are the main sites of aerobic respiration. Under hypoxic conditions, mitochondrial morphology and energymetabolism undergo a series of changes to adapt to the limited oxygen environment. Based on the current research status at home andabroad, this paper analyzes the abnormal mitochondrial energy production, mitochondrial membrane potential and membrane permea-bility changes, calcium ion overload,reactive oxygen species generation overmuch, which of myocardial cells, brain cells, pulmonary ar-tery smooth muscle cells and skeletal muscle cells under hypoxic environment, causing oxidative stress, autophagy phagocytosis andapoptosis, resulting in mitochondrial dysfunction that cause the body tissue damage, and points out the importance of mitochondria inthe process of adapting to hypoxia. Finally, the limitations and future research directions of the current research on the effect of hypox-ia on mitochondria are summarized.