子宫内膜癌的分子机制及分子分型研究进展

子宫内膜癌近年发病呈上升趋势且发病年龄不断年轻化,晚期子宫内膜癌治疗效果不理想.传统的分类方法在患者的诊疗中存在严重的不足,不能为患者精准治疗提供足够的依据.随着分子生物学的快速发展,越来越多的研究发现子宫内膜癌发病的多组学研究和信号通路关联,临床上迫切需要将其纳入患者的常规诊疗中.传统分型根据有无雌激素刺激将子宫内膜...

Research Progress on Molecular Mechanism and Molecular Typing of Endometrial Carcinoma

The incidence of endometrial carcinoma has been on the rise in recent years and the age of onset is getting younger.The treatment effect of advanced endometrial cancer is not ideal.The traditional classification method has serious deficiencies in the diagnosis and treatment of patients,and cannot provide sufficient basis for accurate treatment of patients.With the rapid development of molecular biology,more and more multi-omics studies and signal pathway associations in the onset of endometrial cancer have been discovered,and there is an urgent clinical need to include it in the routine diagnosis and treatment of patients.This article summarizes the latest progress in molecular biology and signaling pathways of type I and type II endometrial carcinoma.The diagnosis and prognosis of type I endometrial carcinoma are related to PTEN,PI3KCA,PI3KR1,ARID1A,KRAS,POLE,CTNNB1,TP53 mutation,MMR deletion,ER and PR expression are related.The prognosis of type II endometrial cancer is related to HER2 overexpression,TP53 mutation,and ARID1A mutation.PI3K/Akt,P53,MAPK and Wnt/β-catenin signaling pathways are closely related to the pathogenesis of endometrial carcinoma.ProMisE and Parra-Herran molecular classification,an alternative to TCGA classification,are currently used clinically to assess the prognosis and treatment options of endometrial carcinoma,but there are still some cases that do not match the prognosis,further refinement of the typing is needed.