4项指标检测对急性肺损伤合并重度感染的预测价值

目的 探讨肝素结合蛋白(HBP)、D-二聚体(DD)、C反应蛋白(CRP)和降钙素原(PCT)检测对于急性肺损伤合并重度感染的预测价值.方法 选择2019年1月至2021年1月就诊的急性肺损伤合并感染患者116例.评估患者入院到出院的临床症状及感染程度,将患者分为重度感染组66例和轻度感染组50例.分别对两组患者入院2...

Predictive value of 4 indicators detection in acute lung injury complicating severe infection

Objective To investigate the predictive value of heparin binding protein(HBP),D-dimer(DD),C-reactive protein(CRP)and procalcitonin(PCT)detection in acute lung injury(ALI)complicating severe infection.Methods One hundred and sixteen patients with ALI complicating infection admitted to this hospital from January 2019 to January 2021 were selected.The clinical symptoms and infection severity from admission to discharge were evaluated.The patients were divided into the severe infection group(66 cases)and mild infection group(50 cases).The levels of HBP,DD,CRP and PCT in the two groups were detected within 2 h after admission,and the distribution situation of HBP,DD,CRP and PCT abnormal results in the two groups were statistically analyzed.The correlation among HBP,DD,CRP and PCT in all cases was analyzed.The receiver operating characteristic(ROC)curve was adopted to analyze the value of each indicator for predicting ALI complicating severe infection.Results The levels of HBP,DD,CRP and PCT in the mild infection group were significantly lower than those in the severe infection group,and the differences were statistically significant(P<0.05).The proportion of DD>232 ng/mL,HBP>15 mg/mL,CRP>10 ng/mL and PCT>0.5 ng/mL in the severe infection group was significantly higher than that in the mild infection group(P<0.05).The correlation analysis results showed that the pairwise indicators of HBP,DD and CRP had the positive correlation,and PCT was positively correlated with HBP(P<0.05).The areas under the curve(AUC)of DD,HBP,CRP and PCT single detection were 0.763,0.815,0.681 and 0.731 respectively(P<0.05).The predictive value of HBP was higher.AUC of the 4-indicator combined detection was 0.808(P<0.05),which was less than 0.815 of HBP.Conclusion There is the positive correlation among HBP,DD and CRP in the patients with ALI complicating severe infection,PCT is positively correlated with HBP,the 4 indicators all have the predictive effect on severe infection,but the effect of HBP is most obvious.