针刺治疗缺血性脑卒中的机制研究进展

通过查阅近年来关于针刺治疗缺血性脑卒中(CIS)的相关文献,发现针刺治疗CIS与抑制神经炎性反应、减轻氧化应激、抑制兴奋性氨基酸毒性、抵抗神经元凋亡、调节自噬、促进神经元再生和修复、促进血管重塑、调节脑血管储备、调节脑代谢、维持血脑屏障完整性等多种作用机制密切相关.本文对以上机制进行归纳总结,以期为临床应用针刺治疗CI...

Research progress on mechanisms of acupuncture in treating ischemic stroke

Cerebral ischemic stroke(CIS) is a common and frequently occurring disease with high morbidity, disability and mortality. In the present paper, we reviewed the progress of studies on the underlying mechanisms of acupuncture in the treatment of CIS in recent years. It is found that acupuncture induced amelioration of symptoms of CIS is closely related to its functions in 1) inhibiting neuroinflammation, 2) reducing oxidative stress, 3) lowering excitatory amino acid toxicity, 4) resisting neuronal apoptosis, 5) regulating cellular autophagy, 6) promoting neuronal regeneration and repair, 7) facilitating vascular remodeling, 8) regulating cerebrovascular reserve, 9) adjusting brain metabolism, and 10) maintaining the integrity of blood-brain barrier. These mechanisms provide scientific basis for clinical application of acupuncture therapy in the treatment of CIS.