| 水通道蛋白在脓毒症中的作用 |
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| 引用本文： | 史永胜,薛龙格,邓红松,吕武洋,梁蕾,金英玉.水通道蛋白在脓毒症中的作用[J].医学分子生物学杂志,2022,19(1):80-84. |
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| 作者姓名： | 史永胜 薛龙格 邓红松 吕武洋 梁蕾 金英玉 |
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| 作者单位： | 哈尔滨医科大学附属第一医院检验科 哈尔滨市, 150001 |
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| 基金项目： | 国家重点研发计划(No.2019YFF0216502)。 |
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| 摘 要： | 脓毒症是世界范围内重症监护病房常见的死亡原因.由于这种免疫综合征的复杂性,迫切需要开发新的治疗策略.水通道蛋白(aquaporins,AQPs)参与脓毒症的多种生理功能,其表达受到不同程度的调控.药物靶点或生物标记物可能存在水通道蛋白(AQPs)上,因为它们是调节脓毒症的关键.对水通道蛋白调节机制的进一步研究可能确定潜...
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| 关 键 词： | 水通道蛋白 免疫细胞 脂多糖 脓毒症 |
Role of Aquaporins in Sepsis |
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| SHI Yongsheng,XUE Longge,DENG Hongsong,LV Wuyang,LIANG Lei,JIN Yingyu.Role of Aquaporins in Sepsis[J].Journal of Medical Molecular Biology,2022,19(1):80-84. |
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| Authors: | SHI Yongsheng XUE Longge DENG Hongsong LV Wuyang LIANG Lei JIN Yingyu |
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| Institution: | (The First Affiliated Hospital of Harbin Medical University,Harbin,150001,China) |
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| Abstract: | Sepsis is a common cause of death in intensive care units worldwide.Due to the com-plexity of this immune syndrome,there is an urgent need to develop new therapeutic strate-gies.Aquaporins(AQPs)are involved in multiple physiological functions in sepsis,and their ex-pression is regulated to varying degrees.AQPs could be used as drug targets or biomarkers for sepsis treatment,as they are key regulators in sepsis.Further studies on the regulation mechanisms of AQPs may help identify potential therapeutic targets for sepsis. |
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| Keywords: | aquaporins immune cells lipopolysaccharide sepsis |
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