动脉粥样硬化多种族研究（MESA)：开创亚临床动脉粥样硬化无创评估新时代

动脉粥样硬化多种族研究（MESA）是美国国家心肺和血液研究所赞助的前瞻性研究,旨在研究性别均衡、多民族、社区居住的美国人群亚临床心血管病的患病率、进展、决定因素和预后意义。MESA开创了无创性评估亚临床动脉粥样硬化及其进展的时代,评估了动脉粥样硬化性心血管病的风险,超越了传统风险因素模型单独预测的能力。MESA的主要研究成果为全球心血管病病人管理指南提供了信息,为有效指导公共卫生政策、人群筛查和临床决策提供了新工具。就MESA的由来、研究目的、研究设计、对心血管医学的贡献以及MESA未来的发展方向予以介绍。

Multi-ethnic study of atherosclerosis: open up a new era of non-invasive assessment of subclinical atherosclerosis

Multi-ethnic study of atherosclerosis (MESA) is a prospective study sponsored by the National Heart, Lung, and Blood Institute to study the prevalence, progress, determinants and prognostic significance of subclinical cardiovascular disease in a gender-balanced, multi-ethnic, community-dwelling American population. MESA ushered in an era of noninvasive assessment of subclinical atherosclerosis and its progess, assessing the risk of atherosclerotic cardiovascular disease, have a better performance than the models built by traditional risk factors alone. The concepts developed by MESA provide information for international patient care guidelines and new tools for effective guidance of public health policy, population screening, and clinical decision-making. This article introduces the background of MESA, research purpose, research design, major contributions of MESA to cardiovascular medicine, and the perspective of MESA in future.