3D生物打印的子宫内膜再生细胞生物支架用于宫腔粘连的探讨

现有的治疗宫腔粘连的方法存在局限性,复发率高,妊娠率低.对子宫内膜再生和功能的恢复几乎无帮助,目前还没有针对该问题最佳的治疗策略.近年来,干细胞成为治疗宫腔粘连的研究热点,而如何维持细胞在体内的生物学活性成为关键问题.3D生物打印技术能够在移植体内模拟细胞体外生存微环境,为移植细胞发挥治疗效应提供了有效的保障.目前已从...

Application of 3D Bioprinted Endometrial Regenerative Cell Biological Scaffold in Intrauterine Adhesions

The existing treatment of intrauterine adhesions has limitations,such as high recurrence rate and low pregnancy rate.There is little help for endometrial regeneration and functional recovery,and there is no optimal treatment strategy for this problem.In recent years,stem cells have become a research focuses in the treatment of intrauterine adhesions,and how to maintain the biological activity of cells in vivo has become a key issue.3D bio-printing technology can simulate the microenvironment of the transplanted cells in vitro,providing an effective guarantee for the therapeutic effect.At present,endometrial regenerative cells(ERC)with the characteristics of stem cells have been obtained from female menstrual blood,and found to have strong proliferative ability and multidirectional differentiation potential.However,it has not been reported whether ERC bio-scaffolds constructed by 3D bioprinting technology can be transplanted to treat intrauterine adhesions.This review briefly introduced the key technologies,cells and bio-inks of 3D bioprinting,and prospected the feasibility and limitations of the application of 3D bioprinted endometrial regenerative cell bioscaffolds for the treatment of intrauterine adhesions.