妊娠早期睡眠质量对妊娠期糖尿病发病风险影响的前瞻性队列研究

目的 分析孕妇妊娠早期睡眠质量对妊娠期糖尿病(gestational diabetes mellitus,GDM)发病风险的影响.方法 于2018年8—12月选取武汉市妇幼保健院产科门诊903例孕妇作为研究对象,采用结构问卷和匹兹堡睡眠质量指数量表(Pittsburg sleep quality index,PSQI)...

Effect of Sleep Quality in Early Pregnancy on Gestational Diabetes Mellitus:A Prospective Cohort Study

Objective To explore the effect of sleep quality during early pregnancy on the risk of gestational diabetes mellitus(GDM).Methods A total of 903 pregnant women were recruited based on a perspective cohort study in Wuhan Maternal and Child Healthcare hospital between August and December 2018.Structural questionnaire and Pittsburgh Sleep Quality Index Scale(PSQI)were used to collect data on the basic information of pregnant women and sleep status in early pregnancy.GDM were diagnosed via oral glucose tolerance test between 24 to 28 gestational weeks.Unconditional logistic regression models were used to evaluate the association between sleep quality and GDM risk.Results Among 903 participants,211 pregnant women were diagnosed as low sleep quality,93 were diagnosed as GDM.The incidence of GDM was 15.5%(33/211)in the low sleep quality group and 8.7%(69/692)in the normal sleep group.There were significant differences in GDM incidence between low sleep quality group and normal sleep group(P=0.004).After adjusting for confounders such as pregnant women's age,education level,pregnancy number,delivery number,BMI before pregnancy,and weight gain during gestation,multivariate logistic regression model analysis showed that sleep continuity(OR=1.79,95%CI:1.44-5.41),sleep pill usage,(OR=1.87,95%CI:1.06-3.28)and poor sleep quality(OR=1.93,95%CI:1.22-3.04)in the first trimester was significantly associated with higher risk of GDM.Conclusion Poor sleep quality of pregnant women in early pregnancy is an independent risk factor for GDM.In order to prevent the GDM,sleep monitoring in the population of pregnant women during prenatal healthcare from early pregnancy is strongly recommended.