针刺治疗脑出血机制的研究进展

本文总结了近20年来针刺治疗脑出血(ICH)继发性损伤的相关机制.归纳发现针刺可以通过抑制炎性反应、减轻脑水肿、抑制凋亡、激活自噬、抑制铁死亡、减轻氧化应激、促进神经再生、改善脑循环、调节神经递质含量、促进血管新生等多种途径治疗IC H继发性损伤.

Progress of researches on mechanisms of acupuncture therapy for cerebral hemorrhage

Acupuncture therapy has been widely used in clinical treatment of consciousness, cognitive function, mental and motor disorders after intracerebral hemorrhage(ICH) in China, and has achieved good results. We, in the present paper, summarized development of studies on the underlying mechanism of acupuncture therapy for ICH in recent 20 years. Outcomes showed that acupuncture can relieve symptoms of ICH by 1) inhibiting inflammatory response, 2) alleviating brain edema, 3) inhibiting apoptosis, 4) activating autophagy, 5) inhibiting iron death, 6) alleviating oxidative stress, 7) promoting nerve regeneration, 8) improving brain circulation, 9) regulating neurotransmitter levels, and 10) promoting angiogenesis. In the future, we suggest that clinical trials for exploring the rule of dialectical acupoint selection in the treatment of ICH should be strengthened, and in-depth studies on the interrelation among the acupuncture targets are conducted to improve the theory of acupuncture effects.