| 基于AGEs的糖尿病在牙周病发展过程的影响机制研究 |
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| 引用本文： | 徐孟丹,孙珍,陶庭亮,鲍利红,邹多宏.基于AGEs的糖尿病在牙周病发展过程的影响机制研究[J].实用口腔医学杂志,2021(2):181-185. |
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| 作者姓名： | 徐孟丹 孙珍 陶庭亮 鲍利红 邹多宏 |
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| 作者单位： | 合肥市口腔医院·安徽医科大学合肥口腔临床学院修复科;上海市第九人民医院 |
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| 摘 要： | 目的:考察糖尿病(T2DM)与牙周病(CP)发病之间的相关性,并探讨其可能的作用机制.方法:60只SD大鼠随机分为4组,每组15只,分别构建T2DM、CP、T2DM合并CP大鼠模型和一组正常对照,4周、8周后,测量大鼠实验区牙周探诊深度和菌斑指数,并用ELISA检测血清中IL-6,TNF-α及AGEs表达水平情况.结果...
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| 关 键 词： | 糖尿病 牙周病 晚期糖基化终末产物 机制 |
A study on the mechanism of AGEs-based diabetes in the development of periodontal disease |
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| XU Mengdan,SUN Zhen,TAO Tingliang,BAO Lihong,ZOU Duohong.A study on the mechanism of AGEs-based diabetes in the development of periodontal disease[J].Journal of Practical Stomatology,2021(2):181-185. |
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| Authors: | XU Mengdan SUN Zhen TAO Tingliang BAO Lihong ZOU Duohong |
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| Institution: | (Department of Prosthodontics,Hefei Stomatology Hospital,Hefei Clinical College of Stomatology of Anhui Medical University,230032China;Shanghai Ninth People's Hospital) |
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| Abstract: | Objective:To investigate the correlation between diabetes(T2DM)and periodontal disease(CP)and the possible mechanism.Methods:60 SD rats were randomly divided into 4 groups(n=15),the rat model of control,T2DM CP and T2DM with CP were established.After 4 and 8 weeks,the periodontal probe depth and plaque index in the experimental area of the rats were measured,the expression levels of IL-6,TNF-and AGEs in serum were detected by ELISA.Results:Compared with the control group,in T2DM and T2DM&CP groups blood glucose increased(P<0.05)after 4 and 8 weeks of model construction,the serum levels of IL-6,TNF-αand AGEs were increased(P<0.05),the gene and protein expression levels of AGEs in the periodontal tissues of T2DM&CP rats were higher than those of the T2DM and CP groups.Conclusion:Diabetes can promote the development of periodontal disease and may be related to the increase of AGEs level. |
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| Keywords: | Diabetes Periodontal disease End products of advanced glycosylation Mechanism |
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