急性脑卒中并多脏器功能衰竭患者NO和SOD测定的临床意义

目的 :通过检测急性脑卒中和卒中并多脏器功能衰竭 (MOF)患者一氧化氮 (NO)及超氧化物歧化酶(SOD) ,以了解自由基对上述疾病变化和预后的临床意义。方法 :分别测定 2 8例脑出血 ,2 6例脑梗死 ,30例急性脑卒中并MOF及 2 5例健康者对照组血浆NO及SOD含量。结果 :急性脑出血、脑梗死组、卒中并MOF组血浆NO明显高于对照组 (P <0 0 1) ,SOD明显低于对照组 (P <0 0 1) ,卒中并MOF死亡组NO含量明显高于存活组 ,SOD明显低于存活组。结论 :氧自由基参与急性脑卒中和急性脑卒中并MOF的病理生理过程 ,故血中NO及SOD的动态变化可作为判断病情发展及预后的指标

Role of detecting NO and SOD in patients with acute cerebral stroke and multiple organ failure

Objective:To determine the role of nitric oxide (NO) and superoxide dimntuse (SOD) plasma levels in patients with acute cerebral stroke.Methods:NO and SOD levels in 25 cerebral bleeding patients,26 cerebral infarction cases,30 acute cerebral stroke patients combined with multiple organ failure (MOF) and 25 healthy controls were investigated respectively.In addition,NO and SOD were measured in stroke death and viable groups.Results:NO was significantly higher,whereas SOD was significantly lower in acute cerebral stroke group than in controls.Moreover,NO was significantly higher whereas SOD was significantly lower in stroke death group than in stroke viable group.Conclusion:Because oxygen free radical is associated with pathophysiological changes of acute cerebral stroke.The present study demonstrates that NO and SOD could serve as prognostic and severity indictive of these patients.