CEA\CA153\CA724联合检测在乳腺癌早期诊断中的临床意义

目的探讨CEA\CA153\CA724联合检测在乳腺癌早期诊断中的临床意义。方法选择我院2010年6月至2011年6月46例乳腺癌患者为观察组,选择同期46例乳腺良性疾病患者为对照组,对两组患者分别使用化学发光法进行血清CEA、CAl53、CA724水平进行检测,观察血清CEA、CAl53、CA724联合检测在乳腺癌早期诊断中的临床意义。结果观察组血清CEA、CAl53水平明显高于对照组,两组比较差异具有显著性,有统计学意义,CA724检测值略高于对照组,但组间比较差异无显著性,无统计学意义(P>0.05)。CEA\CA153\CA724联合检测敏感性为82.6%,特异性为91.8%,敏感性明显高于三种标志物单独检测,其差异具有显著性,有统计学意义(P<0.05)。结论 CEA\CA153\CA724联合检测可以明显提高乳腺癌的检出率。

Clinical Significance of Combined Detection of CEA,CA153 and CA724 in the Early Diagnosis of Breast Cancer

Objective To study the clinical significance of combined detection of CEA,CA153 and CA724 in early diagnosis of breast cancer.Methods 46 patients with breast cancer in our hospital from June 2010 to June 2011were selected as observation group,and 46 cases with benign breast diseases were selected as control group.The serum levels of CEA,CAl53 and CA724 were respectively detected.Results The serum levels of CEA and CAl53 in observation group were significantly higher than those in control group(P <0.05).There was no statistical significance in detection value of CA724 between the two groups(P >0.05).The combined detection of CEA,CA153 and CA724 had the sensitivity rate of 82.6%,and the specificity rate of 91.8%;the sensitivity was obviously higher than single detection of 3 markers in serum(P <0.05).Conclusions The combined detection of CEA,CA153 and CA724 can improve the detection rate of breast cancer.