血清嗜酸性细胞阳离子蛋白与可溶性白细胞介素Ⅱ受体在支气管哮喘中的应用

目的 研究ＥＣＰ与ｓＩＬ－２Ｒ在哮喘病中的致病机制和关系。方法 采用酶免疫荧光法和ＢＡ－ＥＬＩＳＡ法分别测定３０例健康者，６１例重症支气管哮喘患者的血清ＥＣＰ和ｓＩＬ－２Ｒ值，并追踪测试３７例患者治疗后血清ＥＣＰ和ｓＩＬ－２Ｒ水平。结果 急性期患者血清ＥＣＰ，ｓＩＬ－２Ｒ含量均明显高于对照组（Ｐ〈０．０１），治疗后二者水平明显下降，较治疗前非常显著性差异（Ｐ〈０．０１）。结论 ＥＣＰ是促进气道炎症

Changes of Eosinophil cationic protein and Soluble interleukin-2 receptor in Bronchial Asthma

bjective In this study,an attempt was made to clarify theroles played by eosinophil cationoc protein(ECP)and soluble interleukin2 receptor(sIL2R)in the pathogenic mechanism of asthma. Methods The fluorescent enzyme immunoassay(FEIA)and BAELISA were adopted to determine ECP and sIL2R in sera from 30 healthy subjects,61 patients with advanced bronchial asthma.ECP and sIL2R in sera from 37 patients were determined continuously after treatment. Results The results showed that both the levels of ECP and sIL2R in sera from the patients with bronchial asthma in the acute stage were significantly higher than those from the controls(P<001).Both the levels decreased significantly after treatment(P<001). Conclusion ECP is an important inflammatory medium for airway inflammation,and the level of ECP in serum is conductive to the judgment for the activity and the severity of asthmatic airway inflammation.The results indicated that a significant correlation exists between the activation of eosinophil and that of Tlymphocyte,as well as between the increased level of ECP and the activation of Tlymphocyte.