依托咪酯对豚鼠听诱发电位的影响

为探讨听诱发电位能否作为临床麻醉深度监测手段,采用非镇痛性麻醉药依托咪酯分次注入豚鼠腹腔,根据用药剂量模拟浅、中、深度麻醉,观察豚鼠听觉中潜伏期反应及听性脑干反应变化.结果显示,依托咪酯对听觉中潜伏期反应有明显抑制作用,且随麻醉深度加深而增强,但到一定深度后,出现“饱和”现象;中潜伏期反应谱峰明显向低频移动.依托咪酯对浅麻醉时听性脑干反应影响不显著,当麻醉加深时亦出现明显改变.提示中潜伏期反应及听性脑干反应结合使用,可以作为监测麻醉深度的客观电反应指标.

Effect of etomidate on the auditory evoked response in guinea pigs

The effect of Etomidate on the auditory evoked response (MLR and ABR) was carried Out during peritoneal anaesthesia. 11 guinea pigs received a continuous peritoneal infusion of Etomidate. The first dose was 5 mg/kg the secend and third dose while 10 mg/kg are 15 mg/kg respectively. The total of three doses was 30mg/kg over a period of 50 mm . Three equal steps of administration simulated slight,middle and deep anaesthesia.There was an increase in latency of MLR waves A,B,A-B IPL,wave B width, AB/BC amplitude ratio, and decrease in the amplitude of wave C area. The dominant peak of frequency spectrum of MLRshifted to the lower frequencies . There was also an increase in latency of wave I,III,I-III IPL in ABR on the deep anaesthesia stageThese parameters mentioned above showed dose-related changes and can be used as a objective and reliable measures of depth of Etomidate anaesthesia.