门静脉动脉化对肝硬化犬肝切除后肝功能的影响

目的:了解门静脉动脉化(Portal vein arterialization,PVA)对肝硬化犬肝切除后肝功能的影响。方法:随机分为3组:A组(动脉化组):行肝左外叶切除加门静脉动脉化手术;B组(对照组):仅行肝左外叶切除手术;C组(假手术组);每组均于术后4周处死,实验过程中检测肝功能谷草转氨酶(AST)、血浆总蛋白(TP)、血清总胆素红素(TBIL)。结果:术后AST值A组较B组明显降低(P<0.01);TP值A组大于B、C组(P<0.05);TBIL值A组下降快于B组(P<0.01)。结论:门静脉动脉化能改善肝硬化犬部分肝切除后的肝功能。

Study of the effect of portal vein arterialization on the changes of liver function in hepatocirrhosis after partial hepatectomy

Objective:To study the effect of portal vein arterialization(PVA)on the changs of liver function in hepatocirrhosis after party hepatectomy in dogs.Methods:The liver cirrhosis model of dogs was set up.The dogs were divided into three groups randomly,group A(PVA group):partial hepatectomy(42%)plus PVA were given;group B(control group):only partial hepatectomy(42%)was given;group C(sham-operated group).All dogs were killed at four weeks after operations.During the experiment,changes in liver function(AST,TP,TBIL)were observed.Results:After operation,AST of group A was significantly lower than that of group B(P<0.01).TP of group A was significantly higher than those of group B and C(P<0.05). TBIL of group A was fall faster than that of group B(P<0.01).Conclusion:PVA has significantly better effect on liver function after party hepatectomy in hepatocirrhosis dogs.