| 靶向新药时代自体造血干细胞移植在多发性骨髓瘤治疗中的作用 |
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| 引用本文： | 包芳,艾克拜尔·阿布都热衣木,克晓燕.靶向新药时代自体造血干细胞移植在多发性骨髓瘤治疗中的作用[J].白血病．淋巴瘤,2014,23(11):654-657. |
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| 作者姓名： | 包芳 艾克拜尔·阿布都热衣木 克晓燕 |
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| 作者单位： | 1. 100191,北京大学第三医院血液科
2. 新疆维吾尔自治区喀什地区第一人民医院血液科 |
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| 摘 要： | 多发性骨髓瘤（MM）是浆细胞恶性克隆性疾病,自体干细胞移植（ASCT）的加入,增加了大剂量化疗在MM治疗中的优势,使部分患者达到长期生存.即使在靶向新药时代ASCT仍可以明显提高治疗的反应率.靶向新药在ASCT前后联合应用,可辅助提高ASCT的疗效,这是目前使用靶向新药的趋势,但其仍不能取代ASCT在MM治疗中的地位.研究更为合理、有效、低毒的治疗方案是今后的方向.
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| 关 键 词： | 多发性骨髓瘤 自体造血干细胞移植 沙利度胺 来那度胺 硼替佐米 |
Effect of autologous stem cell transplantation on multiple myeloma in the era of targeted novel agents |
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| Bao Fang,Aikebaier·Abudureyimu,Ke Xiaoyan.Effect of autologous stem cell transplantation on multiple myeloma in the era of targeted novel agents[J].Journal of Leukemia & Lymphoma,2014,23(11):654-657. |
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| Authors: | Bao Fang Aikebaier·Abudureyimu Ke Xiaoyan |
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| Institution: | Bao Fang, Aikebaier·Abudureyimu, Ke Xiaoyan (Department of Hematology, Peking University Third Hospital, Beijing 100191, China) |
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| Abstract: | Multiple myeloma （MM） is malignant plasma cell clonal disease.Autologous stem cell transplantation （ASCT） strengthen the advantages of the high-dose chemotherapy in treatment of MM,which achieves long-term survival in some patients.Even in the era of targeted novel agents,ASCT can still obviously increase the response rate of treatment.To improve the therapeutic efficacy,targeted novel agents were administrated before and after ASCT.However,targeted novel agents still cannot replace ASCT therapy in the treatment of MM.The direction of future research is to find more reasonable,effective and low toxic treatment. |
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| Keywords: | Multiple myeloma Autologous stem cell transplantation Thalidomide Lenalidomide Bortezomib |
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