| 消炎痛诱导肝脏金属硫蛋白增加与抗CCl_4损伤 |
| |
| 引用本文： | 唐朝枢,苏静怡,谢国风,李兆萍,宋宗恩,艾南南,章京. 消炎痛诱导肝脏金属硫蛋白增加与抗CCl_4损伤[J]. 北京大学学报(医学版), 1989, 0(5) |
| |
| 作者姓名： | 唐朝枢 苏静怡 谢国风 李兆萍 宋宗恩 艾南南 章京 |
| |
| 作者单位： | 北京医科大学病理生理学教研室，北京医科大学病理生理学教研室，北京医科大学基础医学院，北京医科大学病理生理学教研室，北京医科大学病理生理学教研室，北京医科大学病理生理学教研室，卫生学院中心实验室 84级学生 |
| |
| 摘 要： | 消炎痛5mg/kg腹腔注射,连续三天,诱导大鼠肝脏金属硫蛋白(MT)含量增加21倍;经消炎痛诱导处理的动物CCl_4中毒时肝脂质过氧化产物丙二醛的形成较对照动物减少32％。消炎痛与离体大鼠肝细胞共同孵育6小时,细胞MT含量增加43％。提示消炎痛诱导肝脏MT含量增加可能是其肝保护作用的重要机制之一。
|
| 关 键 词： | 消炎痛 金属硫蛋白 肝中毒 脂质过氧化 |
INDOMETHACIN INDUCED ELEVATION OF HEPATIC METALLOTHIONEIN (MT) SYNTHESIS AND ITS ANTI-INJURIOUS EFFECT ON LIVER WITH CC1_4 INTOXICATION |
| |
| Affiliation: | Department of Pathophysiology Tang Chaoshu |
| |
| Abstract: | It has been reported that indomethacin may induce protective effect on the liver against toxic injury, the mechanism is not known yet. Our work showed that indomethacin in small dosage of 5mg/ kg/day, i. p. for 3 days induced an increase of rat hepatic MT content as high as 21 times. And in the rats intoxicated with CCl4, the hyperperoxidation product malondialdehyde (MDA) in the liver was 32% less than that in the control group. Furthermore, after the isolated rat hepatocytes were incubated with indomethacin for 6h, their MT content increased by 43%, These results indicated that induction of increased hepatic MT synthesis is probably one of the important mechanisms of protective action of indomethacin on the liver. |
| |
| Keywords: | Indomethacin Mctallothionein Liver intoxication Lipid peroxidation |
| 本文献已被 CNKI 等数据库收录！ |
|
