| 戊四氮点燃致大鼠癫痫状态后脑内HSP70的分布研究 |
| |
| 引用本文： | 王玉 阮旭中. 戊四氮点燃致大鼠癫痫状态后脑内HSP70的分布研究[J]. 脑与神经疾病杂志, 1999, 7(3): 129-132 |
| |
| 作者姓名： | 王玉 阮旭中 |
| |
| 作者单位： | 同济医科大学附属同济医院神经内科!430030(王玉，阮旭中)，同济医科大学附属协和医院神经内科(方瑗) |
| |
| 基金项目： | 国家自然科学基金!39330210 |
| |
| 摘 要： | 目的：了解热休克蛋白70（HSP70）在癫痫状态大鼠脑内的分布。方法：应用免疫细胞化学方法观察戊四氮（PTZ）点燃致大鼠癫痫状态后脑内不同区域HSP70的表达。结果：PTZ点燃后大鼠脑CA3区、梨状皮层、杏仁核、丘脑、内嗅皮层、CA1区、顶叶皮层HSP70表达依次减少。结论：HSP70在脑内的表达分布与癫痫脑神经元对兴奋性损伤的耐受性密切相关，可能是癫痫脑神经元选择性脱失的内在机制之一。
|
| 关 键 词： | 热休克蛋白70 戊四氮 点燃 |
The distribution of HSP70 in the brain of rats with status epilepticus induced by PTZ kindling |
| |
| Wang Yu, Rran Xuzhong, Fang Yuan. The distribution of HSP70 in the brain of rats with status epilepticus induced by PTZ kindling[J]. Journal of Brain and Nervous Diseases, 1999, 7(3): 129-132 |
| |
| Authors: | Wang Yu Rran Xuzhong Fang Yuan |
| |
| Affiliation: | Dept of Neurology. Tongji Hospital Tongji Medical University. Wuchan 430030 |
| |
| Abstract: | Objective: To explore the distribution of heat shock protein 70 (HSP70) in the brain of rat with status epilepticus induced by pentylenetetrazol (PTZ) kindling. Methods: The expression of HSP70 in different brain regions were observed in rats with SE induced by pentylenetetrazol (PTZ), via immunocytochemistry. Results: In PTZ Kindled rats. HSP 70 expressed most in CA3 and piriform cortex region. moderate in amygdala and thalamus, least in entorhinal cortex4 CA1 and Parictal cortex.Conclusion: The expreSSional distribution of HSP70 is closly associated with the neuronal susceptability to excito-damage in epileptic brain, and might be one of the mechanisms underlying the selective neuronal loss in the brain of epilepsy. |
| |
| Keywords: | HSP70 pentylenetetrazol kindling |
| 本文献已被 CNKI 维普 等数据库收录！ |
