Glucose absorption in relation to ATP content of the small-intestine mucosa in the dog

Summary From an isolated small-intestine segment of the dog, isotonic glucose solution is better absorbed in vivo from the jejunum than from the ileum. At the same time, the ATP level of the mucosa of different GI tract areas does not vary significantly.Examining the relationship between circulation, glucose absorption and the mucosal ATP content of an isolated jejunal loop, we have ascertained that the decrease of blood supply to a certain limit does not influence the ATP level. A further reduction of the blood flow causes, however, a corresponding decrease of the ATP level. Between absorption of glucose and ATP content of the mucosa, a direct correlation is demonstrable.The possibility of a correlation between the ATP level and the absorption of sugar is discussed.