蛛网膜下腔出血患者神经肽Y的临床研究

目的　观察SAH患者NPY水平改变及其动态变化 ,探讨NPY参与SAH及其伴发病的病理生理机制及其临床意义 ,并探讨其异常分泌的可能机制。方法　选择SAH患者 30例 ,用放免法检测血浆NPY浓度并与正常对照组 2 8例相比较。结果　SAH组与正常对照组NPY水平分别为 5 6 1.15± 2 80 .6 8pg/ml、10 9.80± 87.4 5pg/ml,显著高于对照组 (P <0 .0 0 1)。SAH组NPY的变化规律为 :发病 2 4h内即显著升高 ,1～ 3d进一步升高 ,4～ 7d达峰浓度 ,8～ 15d开始降低 ,15d后下降至正常水平。结论　SAH患者存在NPY分泌异常 ,NPY参与了SAH及其伴发病的病理生理过程。NPY动态检测可作为SAH病情严重程度及预后的重要指标

A Clinical Study on Level of Neuropeptide Y in Plasma in Patients with Subarachnoid Hemorrhage

Objective To observe the levels of neuropeptide Y(NPY) in patients with subarachnoid hemorrhage (SAH) and the relationship between them.And investigate the clinical signiacance of NPY in pathogenetic and pathophysiological mechanism of SAH and its adjuncted diseases.Methods The levels of NPY in plasma were measured by radioimmunoassay in 30 cases with SAH and 28 healthy control subjects.Results The levels of NPY in plasma in the group of SAH increased more than that in the control group. The levels of NPY in plasma in group of SAH started to increase significantly during the first day,continued to increase in 1-3 days,reached the peak concentration in 4-7 days,began to decrease in 8-15 days and decreased to normal level after 15 days.Conclusion SAH patients are abnormal in NPY excreasion.NPY's dynamic measurement can act as the important indication of SAH patient's condition and its prognosis.