| 肝细胞核因子—1α基因A1a98Val变异与中国汉族迟发型2型糖尿病的关系 |
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| 引用本文： | 邓昊,唐炜立,刘征,夏家辉,唐北沙,胡正茂,周智广,邓汉湘,夏昆.肝细胞核因子—1α基因A1a98Val变异与中国汉族迟发型2型糖尿病的关系[J].湖南医科大学学报,2003,28(2):93-94. |
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| 作者姓名： | 邓昊 唐炜立 刘征 夏家辉 唐北沙 胡正茂 周智广 邓汉湘 夏昆 |
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| 作者单位： | [1]中南大学中国医学遗传学国家重点实验室，长沙410078 [2]中南大学湘雅二医院内分泌研究所，长沙410011 |
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| 摘 要： | 目的：探讨肝细胞核因子—1α(HNF—1α)基因外显子1 A1a98Val变弄是否与中国汉族迟发型2型糖尿病相关。方法：选择中国汉族150例迟发型2型糖尿病患者及155例正常对照者，应用聚合酶链反应——限制性片段长度多态(PCR—SSCP)及直接测序法检测A1a98Val变异。结果：受检者均不存在Ala98Val变异。结论：A1a98Val变异不是引起中国汉族迟发型2型糖尿病的重要遗传因素。
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| 关 键 词： | 肝细胞核因子－1α基因 A1a98Val变异 中国 汉族 迟发型 2型糖尿病 |
Relationship between Ala98Val variant of hepatocyte nuclear factor-1 alpha gene and late-onset type 2 diabetes in Han nationality] |
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| Hao Deng,Wei-li Tang,Zheng Liu.Relationship between Ala98Val variant of hepatocyte nuclear factor-1 alpha gene and late-onset type 2 diabetes in Han nationality][J].Bulletin of Hunan Medical University,2003,28(2):93-94. |
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| Authors: | Hao Deng Wei-li Tang Zheng Liu |
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| Institution: | National Laboratory of Medical Genetics, Central South University, Changsha 410078, China. |
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| Abstract: | OBJECTIVE: To ascertain whether Ala98Val variant in exon 1 of hepatocyte nuclear factor-1 alpha (HNF-1 alpha) gene is associated with late-onset Type 2 diabetes in Chinese Han nationality. METHODS: We selected 150 patients with late-onset Type 2 diabetes and 155 controls, and detected Ala98Val variant with polymerase chain reaction-single strand conformational polymorphism(PCR-SSCP) and direct sequencing. RESULTS: None of Ala98Val variant was found in all of the subjects. CONCLUSION: The Ala98Val variant doesn't play an important role in late-onset Type 2 diabetes in Chinese Han nationality. |
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