The protective effect of C-phycocyanin on paraquat-induced acute lung injury in rats |
| |
| Authors: | Sun Yingxin Zhang Juan Yan Yongjian Chi Mingfeng Chen Wenwen Sun Peng Qin Song |
| |
| Affiliation: | aInstitute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China;bDepartment of Postgraduate, Shandong University of Traditional Chinese Medicine, Jinan 250014, China;cShandong Academy of Occupational Health and Occupational Disease, Jinan 250062, China;dThe Athletes Rehabilitation Centre of ShanDong Province, Jinan 250014, China;eDepartment of Pharmaceutical Analysis, Luye Pharmaceutical Limited Company, Yantai 264003, China;fLaboratory of Biological Resources, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, 17 Chunhui Road, Laishan District, Yantai 264003, Shandong Province, China |
| |
| Abstract: | To investigate the potential protective effect of C-phycocyanin (PC) on paraquat (PQ)-induced acute lung injury, rats were divided into control, PQ-treated and PQ + PC-treated groups. Rats in PQ-treated group were orally administered with 50 mg/kg PQ, and rats in PQ + PC-treated group were intraperitoneally injected with 50 mg/kg PC after administration of PQ. At 8, 24, 48 and 72 h after treatments, GSH-Px and SOD activities, MDA levels in plasma and BALF, HYP, NF-κB, IκB-α and TNF-α contents in lung tissues were measured. The pathological changes in lung were observed. After treatment with PC, the levels of MDA and the relative contents of NF-κB and TNF-α were significantly decreased, the activities of GSH-Px and SOD and the relative contents of IκB-α were significantly increased. The degree of rat lung damage was obviously reduced in PQ + PC-treated group. The results suggested that PC treatment significantly attenuated PQ-induced acute lung injury. |
| |
| Keywords: | Abbreviations: PQ, paraquat PC, C-phycocyanin GSH-Px, glutathione peroxidase HYP, hydroxyproline MDA, maleic dialdehyde SOD, superoxide dismutase |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ |
|
