Emerging oseltamivir resistance in seasonal and pandemic influenza A/H1N1 |
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Authors: | Christian Renaud Jane Kuypers Janet A. Englund |
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Affiliation: | aFred Hutchinson Cancer Research Center, 1100 Fairview Ave. North, P.O. Box 19024, D3-100, Seattle, WA 98109-1024, United States;bUniversity of Washington, Molecular Virology Laboratory, 1616 Eastlake Ave East, Suite 320, Seattle, WA 98102-1024, United States;cPediatric Infectious Diseases, Seattle Childrens’ Hospital, 4800 Sand Point Way #R5441, Seattle, WA 98105, United States |
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Abstract: | The emergence of oseltamivir resistance in seasonal and pandemic influenza A/H1N1 has created challenges for diagnosis and clinical management. This review discusses how clinical virology laboratories have handled diagnosis of oseltamivir-resistant H1N1 and what we have learned from clinical studies and case series. Immunocompetent patients infected with oseltamivir-resistant H1N1 have similar outcomes as patients infected with oseltamivir-susceptible H1N1. However, immunocompromised patients infected with oseltamivir-resistant H1N1 experience potentially more risks of complication and transmissibility with few therapeutic options. |
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Keywords: | Abbreviations: HA, hemagglutinin NA, neuraminidase SNP, single nucleotide polymorphism IC50, 50% inhibitory concentration NI, neuraminidase inhibition IV, intra-venous |
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