甲状腺疾病患者血清抗三碘甲腺原氨酸抗体的研究及其临床意义

采用放免法检测１６５例Ｇｒａｖｅｓ病（ＧＤ）患者，１０５例桥本氏甲状腺炎（ＨＴ）患者及１０７例正常人血清抗三碘甲状腺原氨酸抗体（Ｔ３Ａｂ）。结果显示，ＧＤ未治组、缓解组和ＨＴ组Ｔ３Ａｂ的阳性率分别为０．０３６、０．０６９和０．０１９，其中ＧＤ缓解组中２例Ｔ３Ａｂ阳性者，其临床表现与血清Ｔ３和／或ＦＴ３不相符合。正常人Ｔ３Ａｂ皆为阳性。所有Ｔ３Ａｂ阳性的病人血中均可检出甲状腺球蛋白抗体（ＴＧＡｂ）。

Clinical Significance of Detecting Triiodothyronine Autoantibodies in Patients with Thyroid Diseases

The autoantibodies to triiodothyronine (T3Ab) were measured by sensitive radioimmunoassay. T3Ab were de tected in 4 out of 58 patients with remitted Graves' disease(GD), among the 4, 2 patients were clinically discordant with their serum levels of total/or free T3. T3Ab were alao demonstrated in 5 out of 137 patients with untreated GD, and in 2 out of 105 patients with Hashimoto's thyroiditis. However, the same antibodies were not found in 107 healthy control subjects. All the patients with positive T3Ab had antithyroglobulin antibodies (TGAb). The results suggest that T3Ab could be a subpopulation of heterogenous TGAb. And the presence of T3Ab should be suspicious whenever the results of thyroid function tests are discordant with patients' clinical state.