健康老人和老年病患者抗心磷脂抗体的测定

自牛心中提取心磷脂，建立了检测抗心磷脂自身抗体（ACA）的间接ELISA法。检测结果表明，健康人ACA检出率随年龄增高有升高趋势，75岁以上老人最为显著，女性尤甚。高血压病、冠心病、脑梗塞、风心瓣膜病、类风湿性关节炎、糖尿病的老年患者，ACA的检出率均高于年龄匹配的健康对照组，但仅冠心病、风心瓣膜病、类风湿关节炎患者有统计学意义（P＜0．01）。未发现ACA阳性者与阴性者在临床表现上有何显著不同。

Determination of Anticardiolipin Antibody (ACA) in Healthy ElderIy Population and Groups of Elderly Patients

A cardiolipin fraction is extracted from fresh beef heart, an indirect ELISA technique in detection of an-ticardiolipin antibody (ACA) has been established. The results indicate that the detectable rate of ACA is rising asthe healthy population with advancing in age being highest in healthy old people above 75 years old, especially inwomen. ACA positive rates in elderly patients of spontaneous hypertension, coronary heart disease, brain infarc-tion, rheumatic heart diseases, rheumatoid arthritis and diabetes mellitus are noticeably higher than those of con-trol groups, Only in patients of coronary heart disease, rheumatic heart disease and rheumatoid arthritis are statis-tically significant (P<0. 01). But there is no significant differences between the patients with positive ACA andthose with negative ACA in clinical manifestations.