分子检测在个体化肿瘤化疗中的意义

 当前肿瘤治疗策略的确立主要是以循证医学证据为基础，虽比单纯依据经验的治疗迈进了一大步，但仍需经过多次调整,方能找到适合每一患者的最佳药物方案及剂量。而相同疾病的不同患者，由于个体遗传学特性的不同，对同一化疗方案的反应性不尽相同，导致疗效差异巨大。依据个体基因型确定药物类别和药物剂量的模式将开创个体化药物治疗的新纪元。

Molecular diagnosis in personalized therapy for cancer

The current strategies of anti-cancer therapy are mainly based on the evidence-based medicine, which is much better than be based on the doctor's experience. But we still need to make attempts to find the right drugs and doses for each patient. The patients with the same disease may receive different response to the same treatment because of their inherited and somatic genetic variability. This results in greatly different therapeutic outcome. The determination of anti-cancer drugs and the doses based on the individual genotype will open up a new era of personalized therapy.