不同内耳组织抗原免疫致自身免疫性感音神经性聋的研究

目的：探讨不同内耳组织抗原免疫所致内耳主要病理损伤部位和听力障碍类型。方法：采用同种螺旋韧带（ＳＬ）、基底膜（ＢＭ）、螺旋神经节（ＳＧ）组织抗原免疫豚鼠，观察内耳组织病理改变和听觉功能变化。结果：ＳＬＡｇ和ＢＭＡｇ免疫组主要表现耳蜗微音器电位阈值升高和复聪现象，以及蜗管内和血管纹的免疫炎性病理改变；ＳＧＡｇ免疫组主要表现听神经复合动作电位阈值升高和幅值降低，内耳病理变化主要位于蜗轴血管及周围和ＳＧ

Cochlear and retrocochlear deafness induced by immunity with different inner ear tissue antigens

Objectives: To inquire into whether the different inner ear tissue antigens couldcause different kind of hearing loss,and to find out the disorder Positions of auditory system. Meth-ods: The basilar membrane (BM), spiral ligament (SL), and spiral ganglion (SG) of guinea pigs were removed for making antigens,respectively- Then,we used these antigens to immune guineapigs. The special humour and cellular immune reaction, hearing function, and inner earhistopathological changes were observed. Results: In BM-antigen and SL-antigen immune group,the various degrees of cochlear microphonic potential disturbance,recruitment,and immune patho-logical inflammation in cochlear duct and stria vascularis were found. In SG-antigen immune group,auditory nerve compound action potentia1 changes were prondnent,and the iriner ear pathologlcaldamage mainly existed in cochlear axis vesselles or suround areas,and SG. Conclusions:It was com-firmed that the inner ear antigens come from different part of auditory system,which could causecochlear or retrocochlear autoimmune disease.