| 单用和复方中5-单硝酸异山梨醇酯的药动学比较研究 |
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| 引用本文： | 胡蝶,郭宏宝,王银叶,郭绪林. 单用和复方中5-单硝酸异山梨醇酯的药动学比较研究[J]. 中国药学杂志, 2006, 41(24): 1891-1894 |
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| 作者姓名： | 胡蝶 郭宏宝 王银叶 郭绪林 |
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| 作者单位： | 1. 北京大学药学院药理系,北京,100083
2. 北京大学药学院用药物研究所,北京,100083 |
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| 基金项目： | 本校药学院药剂学系卢炜教授在数据处理方面给与热情帮助和指导. |
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| 摘 要： | 目的比较比格犬口服5-单硝酸异山梨醇酯与复方果糖二磷酸钠口服液中的5-单硝酸异山梨醇酯的药动学参数,以研究二者合用对5-单硝酸异山梨醇酯药动学的影响。方法比格犬给药后不同时间采血,用反相高效液相色谱检测血浆中5-ISMN的浓度,用WINBMUPK软件分析数据并计算单用和复方中的5-单硝酸异山梨醇酯的药动学参数,以方差分析和双尾单侧t检验进行比较。结果单用5-单硝酸异山梨醇酯ρmax,AUC0-24h均无明显差异。结论5-单硝酸异山梨醇酯与果糖二磷酸钠组成复方后灌胃给药,对前者的药动学性质无明显影响。
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| 关 键 词： | 5-单硝酸异山梨醇酯 复方果糖二磷酸钠 药动学 |
| 文章编号： | 1001-2494（2006）24-1891-04 |
| 收稿时间： | 2006-01-26 |
| 修稿时间： | 2006-01-26 |
Comparative Pharmacokinetics of Isosorbide-5-Mononitrate and Isosorbide 5-Mononitrate combined with Fluctose-1,6-Diphosphate in Beagles Dogs |
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| HU Die,GUO Hong-bao,WANG Yin-ye,GUO Xu-lin. Comparative Pharmacokinetics of Isosorbide-5-Mononitrate and Isosorbide 5-Mononitrate combined with Fluctose-1,6-Diphosphate in Beagles Dogs[J]. Chinese Pharmaceutical Journal, 2006, 41(24): 1891-1894 |
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| Authors: | HU Die GUO Hong-bao WANG Yin-ye GUO Xu-lin |
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| Affiliation: | a. Department of Pharmacology ; b, Institute of Applied Pharmaceutics, School of Pharmaceutical Sciences, Peking University, Beijing 100083, China |
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| Abstract: | OBJECTIVE To compare the pharmacokinetic properties of isosorbide-5-mononitrate (5-ISMN) with 5-ISMN in fluctose-1,6-diphosphate sodium (FDP) compound. METHODS Male Beagle dogs were orally administrated with either 5-ISMN or 5-ISMN in FDP compound. The plasma concentration of 5-ISMN was measured by reversed-HPLC.The data were analyzed and calculated using WINBMUPK software.RESULTS The pharmacokinetic parameters (such as Ka,K,tmax,ρmax,AUC0-24 h) of 5-ISMN and 5-ISMN in FDP compound did not show significant difference.CONCLUSION The use of fluctose-1,6-diphosphate don't influence the pharmacokinetic properties of 5-ISMN. |
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| Keywords: | isosorbide-5-mononitrate isosorbide-5-mononitrate combined with fluctose-1 6-diphosphate pharmacokinetics |
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