部分肝切除和门静脉阻断对大鼠肝脏氨基比林代谢能力的影响

为观察部分肝切除及相应范围肝脏的门静脉血流阻断后肝脏重量及其代谢功能的变化，采用氨基比林呼吸试验连续检测大鼠肝脏对１４Ｃ氨基比林的去甲基能力并测定了肝脏重量。结果显示：７０％肝切除后２小时，１４ＣＯ２呼气排除率下降５０％，２４小时下降７０％，以后逐渐恢复，２周时接近术前水平。而残肝重量在术后２小时最低，７天时恢复到８０％，１４天恢复正常。９０％肝切除后２小时，１４ＣＯ２呼气排除率下降９０％，全部动物随后迅速死亡。在７０％和９０％肝脏门静脉支结扎后２小时，１４ＣＯ２呼气排除率变化不明显，术后２４小时下降４０％，以后逐渐恢复，２周时达术前水平。而肝总重量除术后２４小时低于对照组外，其余时间与对照组无差别。结果表明，部分肝脏的门静脉血流阻断较相应部分肝切除，不仅可保持术后肝脏解剖重量相对稳定，而且对肝脏代谢功能影响较小

The Effect of Partial Hepatectomy and Portal Vein Occlusion on Aminopyrine Metabolism Capacity of the Liver in Rats

To observe the variation of metabolic function and anatomical weight of the liver after partial hepatectomy and occlusion of portal branches feeding the same magnitude of the liver lobes,hepatic 14 C aminopyrine demethylation capacity determined by aminopyrine breath test and liver weight in rats were examined and compared in series in this study.The results showed that 14 CO 2 expiratory clearance rate was reduced by 50% at 2 hours and by 70% at 24 hours after 70% hepatectomy.Then it increased gradaully and was similar to the preoperative level in 2 weeks.The remnant liver weight was lowest at 2 hours and increased to 80% of the control in 7 days after 70% hepatectomy.It recovered to normal in 2 weeks.In 90% hepatectomy group, 14 CO 2 expiratory clearance rate decreased by 90% at 2 hours after operation.Thereafter,all rats died very soon.In the 2 portal vein occlusion groups, 14 CO 2 expiratory clearance rate had little change at 2 hours and it declined by about 40% at 24 hours after ligation of portal branches feeding 70% or 90% liver mass.It recovered gradually and returned to the preoperative level in 2 weeks.The total liver weight in 2 portal occlusion groups was not significantly different from that in the control except that it was slightly lower than the control at 24 hours after operation.This experimental study suggests that comparing deprivation of portal blood feeding partial liver mass with corresponding partial hepatectomy,the former can not only keep the anatomical liver weight relatively stable but also produce a lesser damage to hepatic metabolic function.