泰州地区中年人群睡眠时间与慢性肾脏疾病的相关性分析

 目的  探讨中国泰州地区的中年人群中自我报告的睡眠时间与慢性肾脏疾病 (chronic kidney disease,CKD)的相关性。方法  数据来自泰州人群健康跟踪调查 (Taizhou Longitudinal Study,TZL)第3阶段35～64岁人群,以血清肌酐作为定义肾脏损伤的指标,采用CKD-EPI公式得出估计肾小球滤过率 (estimate glomerular filtration rate,eGFR),并将eGFR为60～90 mL·min^-1·1.73 m^-2定义为轻度肾功能损伤,将eGFR<60 mL·min^-1·1.73 m^-2定义为 CKD。利用二分类Logistic回归分析睡眠时间和CKD之间的风险关系。结果  在纳入研究的19 450人中短睡眠时间 (≤7 h/天)随着eGFR的下降,在肾功能正常、轻度肾功能损伤及CKD组中的比例逐渐增加,分别为44.5%、 46.7%和52.0% (P<0.001)。在校正一系列变量 (人口统计学、生活方式、健康状态和生化检验)后,短睡眠时间与CKD之间有显著统计学相关性 (OR:1.37,95%CI:1.12～1.68)。而长睡眠时间 (≥9 h/天)与CKD患病率之间没有显著的统计学意义,也未发现睡眠时间与轻度肾功能损伤有统计学关联。结论  在泰州地区35～64岁的中年人群中短睡眠时间与CKD之间有显著的统计学关联。

The association between sleep duration and chronic kidney disease in middle-aged Chinese from Taizhou,China

Objective  To investigate the association between self-reported sleep duration and chronic kidney disease (CKD) among Chinese middle-aged population in Taizhou,Jiangsu Prorince of China. Methods  We used baseline data of subjects aged 35-64 years from Phase Ⅲ of the Taizhou Longitudinal study (TZL).The CKD-EPI equation was used to obtain the estimate glomerular filtration rate (eGFR).Mild renal dysfunction was defined as eGFR ranging from 60 to 90 mL·min^-1·1.73 m^-2,and CKD was defined as eGFR <60 mL·min^-1·1.73 m^-2.Binary logistic regression was used to estimate OR and 95% CI of the risk of CKD. Results  In the 19450 cases finally recruited,short sleep duration (≤7 h /day) was associated with a significant risk of CKD.The frequency of short sleep duration increased by decreased eGFR status (44.5% without CKD,46.7% with mild renal dysfunction and 52.0% with CKD,P<0.001).Short sleep duration was  associated with significantly higher risk of CKD (OR=1.31,95%CI:1.12-1.68) after adjusting for demographics,life style,disease status and laboratory parameters.We did not found any association of long sleep duration (≥9 h/day) with CKD and of sleep duration with mild renal dysfunction. Conclusions  Short sleep duration was related significantly to CKD among middle-aged (35-64 years) Chinese in Taizhou.