Sublingual immunotherapy may affect serum neopterin: Preliminary findings |
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| Authors: | Giorgio Ciprandi Mara De Amici Gianluigi Marseglia Dietmar Fuchs |
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| Affiliation: | 1. Department of Internal Medicine, Azienda Ospedaliera Universitaria San Martino, University of Genoa, Genoa, Italy;2. Pediatric Clinic and Respiratory Clinic, University of Pavia, Foundation IRCCS San Matteo, Pavia, Italy;3. Division of Biological Chemistry, Biocenter, Innsbruck Medical University, Innsbruck, Austria |
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| Abstract: | BackgroundNeopterin is a protein produced by monocytes/macrophages. It has been considered a biomarker of immune activation in several disorders. However, there are few studies in allergic rhinitis (AR).This study evaluated the serum neopterin levels in patients with pollen-induced AR or treated with sublingual immunotherapy (SLIT) and in healthy subjects.Methods146 subjects (70 males, median age 30.5 years): 56 with moderate–severe persistent AR, 40 with AR and successfully treated with 2 year SLIT, and 50 healthy controls were consecutively evaluated outside the pollen season. A skin prick test and blood sampling for assessing serum neopterin levels were performed in all subjects.ResultsSLIT-treated patients had lower neopterin levels than untreated patients and healthy subjects (respectively p = 0.012 and p = 0.0001).ConclusionsNeopterin is a biomarker for immune activation, SLIT may affect serum neopterin probably as a consequence of Treg response to SLIT. |
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| Keywords: | Allergic rhinitis Serum Neopterin Sublingual immunotherapy |
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