| 脑络通激活L—arg—No通路对缺血性脑损伤保护作用 |
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| 引用本文： | 王键,许冠荪.脑络通激活L—arg—No通路对缺血性脑损伤保护作用[J].中国中医基础医学杂志,1998,4(7):36-38. |
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| 作者姓名： | 王键 许冠荪 |
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| 作者单位： | WANG Jian，XU Guansun，LI Jing et al. Anhui College of Traditional Chinese Medicine，Hefei 230038 |
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| 摘 要： | 本文通过建立四动脉夹闭所致大鼠急性全脑缺血—再灌注模型，以脑含水量、局部脑组织血流量（ｒＣＢＦ）、血清和脑组织中一氧化氮（ＮＯ）含量为观察指标，初步研究了脑络通过对缺血性脑损伤保护作用的机理。结果表明：脑络通对缺血性脑损伤具有明显的保护作用，且其作用主要是通过激活Ｌ－ａｒｇ——Ｎｏ通路来实现的。
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| 关 键 词： | 脑络通 一氧化氮 N-亚硝基左旋精氨酸 缺血性脑损伤 局部脑组织血流量 脑水肿 |
Experimental study of the protective effect of Naoluotong on cere broischemia damage in rats by activating L arg NO pathway |
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| WANG Jian,XU Guansun,LI Jing et al. Anhui College of Traditional Chinese Medicine,Hefei.Experimental study of the protective effect of Naoluotong on cere broischemia damage in rats by activating L arg NO pathway[J].Chinese Journal of Basic Medicine In Traditional Chinese Medicine,1998,4(7):36-38. |
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| Authors: | WANG Jian XU Guansun LI Jing Anhui College of Traditional Chinese Medicine Hefei |
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| Institution: | WANG Jian,XU Guansun,LI Jing et al. Anhui College of Traditional Chinese Medicine,Hefei 230038 |
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| Abstract: | To study the protective effect of Naoluotong(NLT) on cerebral ischemia,the acute whole cerebroischemia reperfusion rat model established by 4 occlusion vessels(4 ov) was used.The content of the cerebral tissue water,the regional cerebral blood flow(rCBF) and the nitric oxide(NO) content of brain and serum were observed.The results suggested that NLT can protect brain from ischemic damage by activating L arg NO pathway. |
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| Keywords: | Naoluotong(NLT) nitric oxide(NO) N G nitrio L arginine cerebroischemia damage regional cerebral blood flow(rCBF) brain edema |
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