| MicroRNA在炎症性肠病中的研究进展 |
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| 引用本文： | 徐睿玲. MicroRNA在炎症性肠病中的研究进展[J]. 医学综述, 2012, 18(23): 3944-3947 |
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| 作者姓名： | 徐睿玲 |
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| 作者单位： | 哈尔滨医科大学第二附属医院消化内科,哈尔滨,150086 |
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| 摘 要： | 炎性肠病(IBD)是遗传易感宿主对异常的环境因素作出免疫反应的结果。小分子RNA(MicroRNA,miRNA)是一类长约22个核苷酸、内源性、高度保守的非编码小分子RNA,调控人体多种生理过程。目前发现,miRNA在IBD中表达异常,这可能有助于今后明确IBD的发病机制,并且在疾病的诊断、靶向治疗中有重要意义。
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| 关 键 词： | 炎症性肠病 小分子RNA 炎症 |
Advances in Study of MicroRNA in Inflammatory Bowel Disease |
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| XU Rui-ling. Advances in Study of MicroRNA in Inflammatory Bowel Disease[J]. Medical Recapitulate, 2012, 18(23): 3944-3947 |
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| Authors: | XU Rui-ling |
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| Affiliation: | .(Department of Gastroenterology,Harbin Medical University Second Affiliated Hospital,Harbin 150086,China) |
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| Abstract: | Inflammatory bowel disease(IBD)is the consequence of an abnormal immune response to environmental factors in genetically susceptible hosts.MicroRNA is a class of noncoding small RNA molecules with the features of about 22 nucleotides,endogenous,and highly conservative,which can regulate a variety of human physiological processes.Recently,unique microRNA expression profiles have been described in IBD,which may help to clarify the pathogenesis of IBD,and have a great significance in diagnosis and targeted therapy of IBD in the future. |
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| Keywords: | Inflammatory bowel disease MicroRNA Inflammation |
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