关联负变化与血管性痴呆患者认知障碍的关系

目的 探讨血管性痴呆(vascular dementia,VD）患者关联负变化（contingent negative variation,CNV）的特点。方法 对24例VD患者及22例正常老年人进行CNV测试和比较。结果 VD患者CNV的早成分M1、晚成分M2的潜伏期均较正常人明显延长，且与认知障碍程度密切相关；M1的波幅降低；反应时间（reactive time,RT）延长，且与认知障碍程度密切相关；典型的命令信号后负变化（postimperative negative variation,PINV）出现率增多。结论 CNV值可用于反映VD患者的痴呆程度，且对动态观察VD患者的认知障碍有一定帮助。

Vascular Dementia and Contingent Negative Variation

Purpose To study the characteristics of contingent negative variation (CNV) in vascular dementia. Methods CNV was tested and compared in 24 vascular dementia (VD) patients and 22 normal aged persons. Results The data showed that in compare with normal controls the latencies of early component and late component of CNV in VD were greatly prolonged and closely correlated to the extent of dementia.The amplitude of early component was greatly reduced.The reactive time (RT) was prolonged prominently and also correlated with the extent of dementia.The occurrence of postimperative negative variation (PINV) increased. Conclusions The value of CNV can be used to reflect the extent of dementia.Test the CNV in series may help to evaluate the cognitive impairment in VD.